So Big, by Edna Ferber 

"Winner of the 1924 Pulitzer Prize, So Big is widely regarded as Edna Ferber's crowning achievement. A rollicking panorama of Chicago's high and low life, this stunning novel follows the travails of gambler's daughter Selina Peake DeJong as she struggles to maintain her dignity, her family, and her sanity in the face of monumental challenges." (via amazon.com)